Our platform recapitulates GPCRs with their natural structure, function, and dynamics, using novel bioengineering outside of the cellular environment
Septerna 250 East Grand Avenue South San Francisco, CA 94080
Pioneering A New Era of GPCR Oral Small Molecule Drug Discovery
Powered by The Native Complex Platform™
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Seizing the Opportunity
G protein-coupled receptors (GPCRs) are proteins that help regulate nearly every aspect of human physiology. They have been the most productive target class in drug discovery history, accounting for approximately one-third of all FDA approved pharmaceuticals. The majority of potential GPCR targets, however, have been beyond the reach of modern drug discovery technologies. Until now.
Our Native Complex Platform™ is shifting the paradigm of GPCR drug discovery and bringing previously difficult-to-drug GPCRs into play as therapeutic targets. This creates an opportunity for Septerna to spearhead a new era of GPCR-targeted medicines.
Featured
Septerna Presents New Preclinical Data at ASBMR 2024 Highlighting Therapeutic Potential of Oral Small Molecule Parathyroid Hormone 1 Receptor (PTH1R) Agonists for Hypoparathyroidism
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Functional GPCR Native Complexes Outside of the Cell
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Modern Drug Discovery Technologies Are Now Fully Accessible for GPCRs
The Native Complex Platform™ enables industrial-scale drug discovery, including structure-based drug design and ultra-large-scale screening for the entire GPCR target class for the first time.
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Tackling GPCR Drug Discovery Challenges
With the Native Complex Platform™, novel mechanisms and new opportunities for previously intractable GPCRs come into view for high-impact therapeutic applications.
Real Team. Real Purpose
Septerna is on a mission to make the promise of future GPCR medicines a reality for patients. Our scientists are opening a new frontier in GPCR small molecule discovery technologies to expand the druggable GPCR landscape.
We are always looking for talented and determined individuals to join us to turn this possibility into reality. Bring your real self to Septerna and realize your untapped potential!
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Our Why. Our Story.
Our story starts at the epicenter of GPCR science, with founders and advisors who have made decades of groundbreaking discoveries that reveal the inner workings and molecular pharmacology of this family of receptors that has proven to be a remarkable source of medicines. By coming together to create Septerna and explore our idea of the Native Complex Platform™, these leading scientists provided us with expertise across all aspects of GPCR science and pharmacology.
Septerna’s team of scientists and drug hunters took on the challenge of making the Native Complex Platform™ a reality by building an industrialized platform from the ground up, capable of isolating and controlling GPCRs in a revolutionary new way for drug discovery. We continue to create our story – advancing a deep portfolio of oral small molecule GPCR-targeted programs to treat diseases across multiple therapeutic areas for patients with significant unmet needs.
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team of experts.