Pipeline

A Pipeline for
Real Impact.

View Pipeline
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Native Complex™ Platform Expanding the Landscape of Druggable GPCRs

At Septerna, we are building a pipeline of highly differentiated GPCR-targeted drug discovery and development programs built on our unique Native Complex™ Platform.

We can now reach biologically validated, but historically undruggable GPCRs, as well as the vast majority of unexploited GPCRs still awaiting biological characterization and validation.

The Native Complex™ puts Septerna in a unique position to overcome historical GPCR drug discovery barriers and build a pipeline of new and important medicines for patients.

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Our Pipeline

Real Opportunities: 
Septerna’s Discovery 
Programs

Our initial pipeline of small molecule drug discovery programs focuses on applying novel mechanistic approaches to well-validated GPCR drug targets.

This diversified portfolio spans multiple therapeutic areas and creates the opportunity for the next generation of first-in-class and best-in-class GPCR medicines.

Target

Endocrine Target

Mode of Action

Negative Allosteric Modulator

Discovery

Target

CNS Target

Mode of Action

Agonist

Discovery

Target

Endocrine Target

Mode of Action

Agonist

Discovery

Target

Inflammation Target

Mode of Action

Negative Allosteric Modulator

Discovery

Target

Metabolic Target

Mode of Action

Agonist

Discovery

Target

Mode of Action

Discovery

IND Enabling

Clinical

Endocrine Target

Negative Allosteric Modulator

CNS Target

Agonist

Endocrine Target

Agonist

Inflammation Target

Negative Allosteric Modulator

Metabolic Target

Agonist