Making it Real.

A New Era of GPCR Drug Discovery

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Seizing the Opportunity

G protein-coupled receptors (GPCRs) are proteins that help regulate virtually every aspect of human physiology. They are one of the most abundant drug target classes in human health and disease, and the source of one‑third of all approved pharmaceuticals. The vast majority of potential GPCR targets, however, have been beyond the reach of modern drug discovery technologies. Until now.

Septerna is changing the game. Our Native Complex™ Platform is shifting the paradigm of GPCR drug discovery and bringing previously “undruggable” GPCRs into play as therapeutic targets. This creates an unprecedented opportunity for Septerna to spearhead a new era of GPCR-targeted medicines.

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Featured News

Septerna Appoints Jeffrey Finer, MD, PhD, as Chief Executive Officer

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Our ScienceOur ScienceOur ScienceOur ScienceOur ScienceOur ScienceOur ScienceOur ScienceOur ScienceOur Science

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01

A First: Functional GPCR Native Complexes™ Outside of the Cell

Our platform recapitulates GPCRs with their native structure, function, and dynamics, using novel bioengineering outside of the cellular environment.

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Modern Drug Discovery Technologies Are Now Fully Accessible for GPCRs

The Native Complex™ enables industrial-scale drug discovery, including structure-based drug design and ultra-large-scale screening for the entire GPCR target class for the first time.

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Septerna is Leading the Way with Best-in-Class GPCR-Targeted Medicines

With the Native Complex™ Platform, novel mechanisms and new opportunities for previously intractable GPCRs come into view for high-impact therapeutic applications.

Real Team. Real Purpose.

Septerna is on a mission to make the promise of future GPCR medicines a reality for patients. Our scientists are opening a new frontier in GPCR small molecule discovery technologies to expand the druggable GPCR landscape.

We are always looking for talented and determined individuals to collaborate with us to turn this possibility into reality. Bring your real self to Septerna and realize your untapped potential!

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Our Why. Our Story.

Our story starts at the epicenter of GPCR science, with founders and advisors who have made decades of groundbreaking discoveries that reveal the inner workings and molecular pharmacology of this family of receptors that has proven to be a remarkable source of medicines. In coming together to create Septerna and explore our idea of the Native Complex™, these leading scientists provide us with an unmatched brain trust across all aspects of GPCR science and pharmacology.

As Septerna crystallized, our team of scientists and drug hunters took on the challenge of making the Native Complex™ a reality by building an industrialized platform from the ground up, capable of isolating and controlling GPCRs in a revolutionary new way for drug discovery. We continue to create our story – advancing our first small molecule drug discovery programs on the way to creating meaningful future medicines for patients.

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Join Our Team

Join our growing

team of experts.

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